The Holy Texts Of God-Allah-Yahweh.

The Holy Texts Of God-Allah-Yahweh.

Tanakh1917

the-torah

kjvbible

AV1611

Quran-Translation-in-English-by-Mufti-Taqi-Usmani-Sb-DB

Quran-with-English-Translation

Do your research and learn from more than one text to know God-Allah-Yahweh, his commandments/laws, and the Kingdom of Heaven.

In these EndTimes we give you a simple prayer.

God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The EVIL And Their Followers.

Will The Pandemic End Soon?

Will The Pandemic End Soon? Check it out. It appears antiviral and antibiotic cures Covid 19 in 6 days.

https://docs.google.com/document/d/e/2PACX-1vTi-g18ftNZUMRAj2SwRPodtscFio7bJ7GdNgbJAGbdfF67WuRJB3ZsidgpidB2eocFHAVjIL-7deJ7/pub

An Effective Treatment for Coronavirus (COVID-19)

Presented by: James M. Todaro, MD (Columbia MD, jtodaro2@gmail.com) and Gregory J. Rigano, Esq. (grigano1@jhu.edu)

In consultation with Stanford University School of Medicine, UAB School of Medicine and National Academy of Sciences researchers.

March 13, 2020

SPANISH: https://docs.google.com/document/d/e/2PACX-1vR1adodKPhWalV9djnerI2x_v1LGgGyhZZxpl0O5r-ZNyDdagqFq1rTCxXBqaeicfxgvypDOqKCZVyV/pub

    Translation by: Celia Martínez-Aceves (Yale B.S. Candidate 2021; celia.martinez-aceves@yale.edu),  Martín Martínez (MIT B.S. 2017 ; martin.martinez.mit@gmail.com)

ITALIAN: https://docs.google.com/document/d/e/2PACX-1vSjPNh_WX6FXUIE3OaA3ScsW7yIH3-SpZyYzElNQUNuJvDmD9eFzM29mVXeaYRY-rjGv52wkrZNa7tb/pub

    Translation by: Google Translate and edited by Ross Shulman, Cornell University MS '20 ross.shulman@gmail.com

Summary

Recent guidelines from South Korea and China report that chloroquine is an effective antiviral therapeutic treatment against Coronavirus Disease 2019. Use of chloroquine (tablets) is showing favorable outcomes in humans infected with Coronavirus including faster time to recovery and shorter hospital stay. US CDC research shows that chloroquine also has strong potential as a prophylactic (preventative) measure against coronavirus in the lab, while we wait for a vaccine to be developed. Chloroquine is an inexpensive, globally available drug that has been in widespread human use since 1945 against malaria, autoimmune and various other conditions.

Chloroquine: C18H26ClN3

Background

The U.S. CDC and World Health Organization have not published treatment measures against Coronavirus disease 2019 (“COVID-19”). Medical centers are starting to have issues with traditional protocols. Treatments, and ideally a preventative measure, are needed. South Korea and China have had significantly more exposure and time to analyze diagnostic, treatment and preventative options. The U.S., Europe and the rest of the world can learn from their experience. According to former FDA commissioner, board member of Pfizer and Illumina, Scott Gotlieb MD, the world can learn the most about COVID-19 by paying closest attention to the response of countries that have had significant exposure to COVID-19 before the U.S. and Europe.[1]

As per the U.S. CDC, “Chloroquine (also known as chloroquine phosphate) is an antimalarial medicine… Chloroquine is available in the United States by prescription only… Chloroquine can be prescribed for either prevention or treatment of malaria. Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant women and nursing mothers.”[2]

CDC research also shows that “chloroquine can affect virus infection in many ways, and the antiviral effect depends in part on the extent to which the virus utilizes endosomes for entry. Chloroquine has been widely used to treat human diseases, such as malaria, amoebiosis, HIV, and autoimmune diseases, without significant detrimental side effects.”[3]

The treatment guidelines of both South Korea and China against COVID-19 are generally consistent, outlining chloroquine as an effective treatment.

Specifically, according to the Korea Biomedical Review, in February 2020 in South Korea, the COVID-19 Central Clinical Task Force, composed of physicians and experts treating patients agreed upon treatment principles for patients with COVID-19.[4] In China, the General Office of the National Health Commission, General Office of the State Administration of Traditional Chinese Medicine as well as a Multi-Center Collaborative Group of Guangdong Provincial Department of Science and Technology and Guangdong Provincial Health Comp and the China National Center for Biotechnology Development have established effective treatment measures based on human studies.[5]

According to their research (reported in Clinical Trials Arena),

“Data from the drug’s [chloroquine] studies showed ‘certain curative effect’ with ‘fairly good efficacy’ … patients treated with chloroquine demonstrated a better drop in fever, improvement of lung CT images, and required a shorter time to recover compared to parallel groups. The percentage of patients with negative viral nucleic acid tests was also higher with the anti-malarial drug… Chloroquine has so far shown no obvious serious adverse reactions in more than 100 participants in the trials… Chloroquine was selected after several screening rounds of thousands of existing drugs. Chloroquine is undergoing further trials in more than ten hospitals in Beijing, Guangdong province and Hunnan province.”[6]

Treatment Guidelines from South Korea[7]

According to the Korea Biomedical Review, the South Korean COVID-19 Central Clinical Task Force guidelines are as follows:

  1. If patients are young, healthy, and have mild symptoms without underlying conditions, doctors can observe them without antiviral treatment;
  2. If more than 10 days have passed since the onset of the illness and the symptoms are mild, physicians do not have to start an antiviral medication;
  3. However, if patients are old or have underlying conditions with serious symptoms, physicians should consider an antiviral treatment. If they decide to use the antiviral therapy, they should start the administration as soon as possible:

… chloroquine 500mg orally per day.

  1. As chloroquine is not available in Korea, doctors could consider hydroxychloroquine 400mg orally per day (Hydroxychloroquine is an analog of chloroquine used against malaria, autoimmune disorders, etc. It is widely available as well).
  2. The treatment is suitable for 7 – 10 days, which can be shortened or extended depending on clinical progress.

Notably, the guidelines mention other antivirals as further lines of defense, including anti-HIV drugs.

Treatment Guidelines from China[8]

According to China’s Novel Coronavirus Pneumonia Diagnosis and Treatment Plan, 7th Edition, the treatment guidelines are as follows:

  1. Treatment for mild cases includes bed rest, supportive treatments, and maintenance of caloric intake. Pay attention to fluid and electrolyte balance and maintain homeostasis. Closely monitor the patient’s vitals and oxygen saturation.
  2. As indicated by clinical presentations, monitor the hematology panel, routine urinalysis, CRP, biochemistry (liver enzymes, cardiac enzymes, kidney function), coagulation, arterial blood gas analysis, chest radiography, and so on. Cytokines can be tested, if possible.
  3. Administer effective oxygenation measures promptly, including nasal catheter, oxygen mask, and high flow nasal cannula. If conditions allow, a hydrogen-oxygen gas mix (H2/O2: 66.6%/33.3%) may be used for breathing.
  4. Antiviral therapies:

… chloroquine phosphate (adult 18-65 years old weighing more than 50kg: 500mg twice daily for 7 days; bodyweight less than 50kg: 500mg twice daily for day 1 and 2, 500mg once daily for day 3 through 7) …

Additionally, the Guangdong Provincial Department of Science and Technology and the Guangdong Provincial Health and Health Commission issued a report stating “Expert consensus on chloroquine phosphate for new coronavirus pneumonia: … clinical research results show that chloroquine improves the success rate of treatment and shortens the length of patient’s hospital stay.”[9] The report further goes on to cite research from the US CDC from 2005 as well as research from the University of Leuven University in Belgium regarding chloroquine’s effectiveness against SARS coronavirus at the cellular level.[10]

Like the South Korean guidelines, notably, other antivirals (e.g. anti-HIV drugs) are listed as further lines of defense. The most research thus far has been around chloroquine.

Chloroquine as a prophylactic (preventative) measure against COVID-19[11]

According to research by the US CDC, chloroquine has strong antiviral effects on SARS coronavirus, both prophylactically and therapeutically. SARS coronavirus has significant similarities to COVID-19. Specifically, the CDC research was completed in primate cells using chloroquine’s well known function of elevating endosomal pH. The results show that “We have identified chloroquine as an effective antiviral agent for SARS-CoV in cell culture conditions, as evidenced by its inhibitory effect when the drug was added prior to infection or after the initiation and establishment of infection. The fact that chloroquine exerts an antiviral effect during pre- and post-infection conditions suggest that it is likely to have both prophylactic and therapeutic advantages.”

The study shows that chloroquine is effective in preventing SARS-CoV infection in cell culture if the drug is added to the cells 24 h prior to infection.

FIGURE 1

Prophylactic effect of chloroquine. Vero E6 cells pre-treated with chloroquine for 20 hrs. Chloroquine-containing media were removed and the cells were washed with phosphate buffered saline before they were infected with SARS-CoV (0.5 multiplicity of infection) for 1 h in the absence of chloroquine. Virus was then removed and the cells were maintained in Opti-MEM (Invitrogen) for 16–18 h in the absence of chloroquine. SARS-CoV antigens were stained with virus-specific HMAF, followed by FITC-conjugated secondary antibodies. (A) The concentration of chloroquine used is indicated on the top of each panel. (B) SARS-CoV antigen-positive cells at three random locations were captured by using a digital camera, the number of antigen-positive cells was determined, and the average inhibition was calculated. Percent inhibition was obtained by considering the untreated control as 0% inhibition. The vertical bars represent the range of SEM.

In the case of chloroquine treatment prior to infection, the impairment of terminal glycosylation of ACE2 may result in reduced binding affinities between ACE2 and SARS-CoV spike protein and negatively influence the initiation of SARS-CoV infection. The cell surface expression of under-glycosylated ACE2 and its poor affinity to SARS-CoV spike protein may be the primary mechanism by which infection is prevented by drug pretreatment of cells prior to infection.

In addition, the study also shows that chloroquine was very effective even when the drug was added 3–5 h after infection, suggesting an antiviral effect even after the establishment of infection.

Figure 2

Post-infection chloroquine treatment reduces SARS-CoV infection and spread. Vero E6 cells were seeded and infected as described for Fig. 1 except that chloroquine was added only after virus adsorption. Cells were maintained in Opti-MEM (Invitrogen) containing chloroquine for 16–18 h, after which they were processed for immunofluorescence. (A) The concentration of chloroquine is indicated on the top. (B) Percent inhibition and SEM were calculated as in Fig. 1B. (C) The effective dose (ED50) was calculated using commercially available software (Grafit, version 4, Erithacus Software).

When chloroquine is added after infection, it can rapidly raise the pH and subvert on-going fusion events between virus and endosomes, thus inhibiting the infection. When added after the initiation of infection, it likely affects the endosome-mediated fusion, subsequent virus replication, or assembly and release. Specifically, rapid elevation of endosomal pH and abrogation of virus-endosome fusion may be the primary mechanism by which virus infection is prevented under post-treatment conditions.

The US CDC study goes on to conclude that:

“The infectivity of coronaviruses other than SARS-CoV are also affected by chloroquine, as exemplified by the human CoV-229E [15]. The inhibitory effects observed on SARS-CoV infectivity and cell spread occurred in the presence of 1–10 µM chloroquine, which are plasma concentrations achievable during the prophylaxis and treatment of malaria (varying from 1.6–12.5 µM) [26] and hence are well tolerated by patients. Chloroquine, a relatively safe, effective and cheap drug used for treating many human diseases including malaria, amoebiasis and human immunodeficiency virus is effective in inhibiting the infection and spread of SARS CoV in cell culture.”

COVID-19 and Chloroquine: Mechanisms of Action[12]

COVID-19 in a single stranded, positive strain RNA virus with a protein shell and membrane. The genome is of the same sense of the mRNA. It goes through a lifecycle where incoming viral COVID genome has to become double stranded RNA and the new strand becomes the new strand for the new mRNA. There are significant similarities between COVID-19 and SARS coronavirus. Both COVID-19 and SARS-like coronaviruses have machinery for regulating their own replication and production of their proteins. Coronavirus depends on the breakdown of macromolecules such as proteins. Specifically, the virus depends on turning over the host proteins to trigger response for available building blocks to make their own proteins or nucleic acids. They break down due to low PH catalyzed by hydrolysis. Additionally, coronaviruses have non-structural proteins that are not part of the capsid (protein shell of the virus). These non-structural proteins are regulatory proteins that take over the host cell and suppress the immune system of the host (similar to HIV). Coronavirus can create growth factor like mechanisms (e.g. cytokines) to optimize the growth environment in the cell to favor it.

It is this part of the coronavirus’ replicative path that chloroquine inhibits. Notably, because of its nitrogen structure, chloroquine has the unique ability to get into cells and cross endosomal membranes. Once inside, nitrogens in chloroquine (and quinines in general) prevent acidification by absorbing a high amount of hydrogens that simply then interact with nitrogen and then chloroquine becomes positively charged – an ionic interaction which makes it harder for the endosome to become acidified. The result is a buffer that holds it at the higher pH and prevents it from becoming acidic enough to be functional. To summarize, because chloroquine has a multitude of extra nitrogens, once it crosses the membrane and enters an organelle, the organelle is prevented from reaching a lower pH. The organelle’s enzymes cannot work because the donor group will be a hydrogen ion, disabling the hydrolysis required for coronavirus replication. This means that all kinds of events in the cell are incapable of performing optimally, including viral replication.

Chloroquine’s entrance into the organelle likely constipates the whole system. An analogy is that the virus is like a garbage facility which has to break down and burn up the garbage and if it cannot, the garbage piles up and the city becomes paralyzed. This is likely the case for any virus, cancer cells or any other condition that is dependent on turning over the worn out or incorrectly synthesized proteins.

The UK has banned the export of Chloroquine[13]

As of February 26, 2020, the UK government has added chloroquine to the list of medicines that cannot be parallel exported from the UK. Chloroquine was never on this list before. This likely happened because of the growing body of evidence of chloroquine’s effectiveness against coronavirus.

China prioritizes internal use of Active Pharmaceutical Ingredients (APIs) including Chloroquine[14]

In early February, Chongqing Kangle Pharmaceutical was requested by the Ministry of Industry and Information Technology, Consumption Division to promptly increase the manufacturing and production of the active pharmaceutical ingredients chloroquine phosphate despite slowed production during the Chinese New Year.

Key Risks and Tradeoffs

There has been massive de-stabilization of society due to COVID-19.

Mutations[15]

RNA viruses are subject to fairly high mutation rates as RNA based genomes do not copy themselves faithfully, thereby accumulating mutations quickly which can lead to failure of the virus (analogy: unaudited software code will often eventually fail due to a critical error) or can lead to a stronger mutation – which is likely what has happened in 2020 (when coronavirus “jumped” from animal to human; it is doubtful that this has occurred because of the use of chloroquine) as we have have two forms of COVID-19 (“more aggressive” and “less aggressive”). If the replication quality of RNA virus like coronavirus can be destabilized this will likely cause it to self destruct, but there is always the risk that the virus mutates to become more aggressive.

Treating COVID-19 with chloroquine, as is being done in South Korea and China does have the potential to lead to a mutation. The mutation can either be beneficial or harmful to humans. In this particular case, chloroquine is likely being used to destabilize the replication quality of COVID-19, providing significant potential for COVID-19 to self-destruct, which would likely bide more time for health systems worldwide to increase capacity and equipment as well as allow time for the public release of a vaccine. All precaution must be taken into account for the risk of escape where COVID-19 comes out stronger.

Manufacturing

Chloroquine and its analogs has been manufactured and distributed at global scale since approximately 1945. While there has recently been a shortage of N95 protective masks, medical systems can adjust and dramatically increase the supply of chloroquine in the world. Chloroquine tablets and intravenous formulations are generic and easy to produce.

Safety[16]

Chloroquine is a prescription drug. It can have side effects and has contraindications. One often cited side effect is chloroquine retinopathy, which can result in permanent vision loss after high cumulative doses of chloroquine. However, retinal damage is extremely rare in patients with a total dosage under 400g (dosage level only reached after years of treatment). Medical professionals must be consulted before use of chloroquine. Chloroquine tablets are readily available in the U.S. and have never been removed from the market. Intravenous chloroquine was taken off the market in the USA pre-2000 because of the absence of acute malarial infections in the USA – there was no use for the intravenous form. It can easily be brought back to the market.

Formulation Optimizations[17]

Tablet vs. Intravenous

Currently chloroquine is most widely administered in tablet form (chloroquine phosphate. While readily available, the issue is that when the tablet is ingested, it must be processed through the stomach and be taken up by the small intestine, for which then it enters the blood and subsequently the respiratory system. Because of the metabolism, this takes time and there is a loss of chloroquine delivery to the respiratory system (where COVID-19 replicates).

When chloroquine is used intravenously against malaria (chloroquine hydrochloride), it is being mainlined directly into the blood stream so that it is distributing around the body within seconds, likely encountering the virus faster and at a higher concentration in the respiratory system. Intravenous formulations are readily available and should be studied accordingly.

Further research should be carried out using chloroquine in nanoparticles and various fast, slow and sustained released formulations, as well as combinations of chloroquine and other molecules.

Repurposing other FDA approved drugs

As per Steve Schow PhD, Professor of Chemical and Systems Biology at Stanford University School of Medicine and Lead Advisor to Stanford’s SPARK Translational Research Program:

“There are a number of related isoquinoline and quinoline drug family members who might exhibit the same general acid neutralizing effects. In addition certain antidepressants and antipsychotic drugs are known to accumulate in lysosomes via this acid-base process and might be effective here if the doses needed aren’t too high.”[18]

New Molecular Entity: Chloroquine analogs with more nitrogens

The nitrogens in chloroquine and quinines in general prevent acidification by absorbing a high amount of hydrogens that then interact with nitrogen, and,in turn, transfer a positive charge to chloroquine. This ionic interaction makes it harder and harder for the endosome to become acidified, therefore disrupting viral replication. If more nitrogens are added, either by making extra branches of ionizable nitrogens or lengthening one of the chains by putting extra carbons and other nitrogens around it, this may have even greater effect. The key issue will be whether there is a heavy change in bioavailability – will the new molecule be able to enter the cell and reach the right place with similar efficiency.

Conclusion

Chloroquine can both prevent and treat malaria. Chloroquine can both prevent and treat coronavirus in primate cells (Figure 1 and Figure 2). According to South Korean and China human treatment guidelines, chloroquine is effective in treating COVID-19. Given chloroquine’s human safety profile and existence, it can be implemented today in the U.S., Europe and the rest of the world. Medical doctors may be reluctant to prescribe chloroquine to treat COVID-19 since it is not FDA approved for this use. The United States of America and other countries should immediately authorize and indemnify medical doctors for prescribing chloroquine to treat COVID-19. We must explore whether chloroquine can safely serve as a preventative measure prior to infection of COVID-19 to stop further spread of this highly contagious virus.

More Sources

Griffero-Diaz’s F. , Hoschander SA , Brojatsch J .Endocytosis IS A Critical entry in STEP B of subgroup Avian leukosis viruses[J].J Virology,2003,76(24):12866-12876.The DOI: 10.1128 / jvi.76.24. 12866-12876.2002 .

Rodrigo D , Luiza H , Paula P , et al .Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models[J].Viruses,2016,8(12):322-.DOI: 10.3390 / v8120322 .

Zhang S , Yi C , of Li C , et Al .Chloroquine inhibits the endosomal Viral an RNA Release and autophagy in-dependent Viral Replication and Effectively Prevents CARE OF to Fetal Transmission of Zika Virus. [J] Antiviral Res.2019;169:104 547. The DOI: 10.1016 /j.antiviral.2019.104547

Kono M , Tatsumi K , Imai AM , et al .Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK[J].Antiviral Res,2008,77(2):150-152.DOI: 10.1016 / j.antiviral.2007.10.011 .

Didier Raoult, et. al. , Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 International Journal of Antimicrobial Agents

Available online 4 March 2020, https://www.sciencedirect.com/science/article/pii/S0924857920300820?via%3Dihub#!

Next Steps from the Community

1Disseminate this publication amongst the medical community. Get more feedback.
2Send this publication to your scientific contacts in South Korea and China – lets get more data, details, etc. Science never ends.
3Translate this paper into all languages.
4Explore all options for use of chloroquine against any medical condition that depends on the turnover of worn out or incorrectly synthesized proteins.

Acknowledgements

Special thanks to Stanford University School of Medicine, SPARK Translational Research Program, Steve Schow, PhD, The Lab of Louise T. Chow, PhD and Thomas R. Broker, PhD, Bruce Bloom DDS, JD of HealX and Adrian Bye.

License

Due to urgency, certain parts of this publication are taken directly from their attributed source. Cite them accordingly.

In all other circumstances, the GNU General Public License v3.0 applies.

Disclaimer

This white paper is for information purposes only. The authors and or its affiliates does not guarantee the accuracy of or the conclusions reached in this white paper, and this white paper is provided “as is”. The authors and or its affiliates not make and expressly disclaims all representations and warranties, express, implied, statutory or otherwise, whatsoever, including, but not limited to: (i) warranties of merchantability, fitness for a particular purpose, suitability, usage, title or noninfringement; (ii) that the contents of this white paper are free from error; and (iii) that such contents will not infringe third-party rights. The authors and or its affiliates shall have no liability for damages of any kind arising out of the use, reference to, or reliance on this white paper or any of the content contained herein, even if advised of the possibility of such damages. In no event will the authors and or its affiliates be liable to any person or entity for any damages, losses, liabilities, costs or expenses of any kind, whether direct or indirect, consequential, compensatory, incidental, actual, exemplary, punitive or special for the use of, reference to, or reliance on this white paper or any of the content contained herein, including, without limitation, any loss of business, revenues, profits, data, use, goodwill or other intangible losses. All translations are done voluntarily by third-parties for which the authors have no affiliation – we do not attest to their accuracy.

Informational Purposes Only

[1] https://www.cnbc.com/video/2020/03/02/coronavirus-testing-emergency-room-doctor-cdc-department-health-squawk-box.html

[2] https://www.cdc.gov/malaria/resources/pdf/fsp/drugs/Chloroquine.pdf

[3] Vincent, Martin J et al. “Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.” Virology journal vol. 2 69. 22 Aug. 2005, doi:10.1186/1743-422X-2-69 , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B15. Savarino A, Boelaert JR, Cassone A, Majori G, Cauda R. Effects of chloroquine on viral infections: an old drug against today’s diseases? Lancet Infect Dis. 2003;3:722–727. doi: 10.1016/S1473-3099(03)00806-5.

[4] http://www.koreabiomed.com/news/articleView.html?idxno=7428

[5] https://www.ncbi.nlm.nih.gov/pubmed/32075365/ ; http://www.nhc.gov.cn/yzygj/s7653p/202002/0293d017621941f6b2a4890035243730.shtml translated as https://www.chinalawtranslate.com/en/chloroquine-phosphate/ ; Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 7th Edition)

translated as https://www.chinalawtranslate.com/en/coronavirus-treatment-plan-7/ ; https://www.clinicaltrialsarena.com/news/coronavirus-covid-19-choroquine-data/ .

[6] https://www.clinicaltrialsarena.com/news/coronavirus-covid-19-choroquine-data/ . This research must be confirmed and furthermore ruled out that the subjects that had negative viral nucleic acid tests might not have been infected with C-19.

[7] http://www.koreabiomed.com/news/articleView.html?idxno=7428

[8] Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 7th Edition)translated as https://www.chinalawtranslate.com/en/coronavirus-treatment-plan-7/

[9] https://www.ncbi.nlm.nih.gov/pubmed/32075365/ Guangdong Provincial Science and Technology Department and Guangdong Provincial Health and Health Commission’s Multicenter Collaboration Group on Chloroquine Phosphate for New Coronavirus Pneumonia. Expert Consensus on Chloroquine Phosphate for New Coronavirus Pneumonia [J / OL]. Chinese Journal of Tuberculosis and Respiratory Medicine, 2020,43 (2020-02-20) .http: //rs.yiigle.com/yufabiao/1182323.htm.

[10] US CDC, Vincent MJ , Bergeron E , Benjannet S , et Al .Chloroquine IS A potent inhibitor of SARS coronavirus Infection and Spread of[J].Virology Journal,2005,2(. 1):69.The DOI: 10.1186 / 1743-422X-2-69 . Keyaerts E , Vijgen L , Maes P , et Al .The In Journal Severe acute Inhibition of Respiratory syndrome coronavirus by chloroquine[J].Biochem Biophys Res Communications,2004,323(. 1):0-268.The DOI: 10.1016 / j.bbrc .2004.08.085 .

[11] All research from this section is from: US CDC, Vincent MJ , Bergeron E , Benjannet S , et Al .Chloroquine IS A potent inhibitor of SARS coronavirus Infection and Spread of[J].Virology Journal,2005,2(. 1):69.The DOI: 10.1186 / 1743-422X-2-69

[12] All research from this section is from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147684/ , https://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1182-0#citeas ,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/#B15 , https://www.nature.com/articles/s41422-020-0282-0 , Thomas R. Broker, PhD, Stanford University School of Medicine, Telephone discussion March 12, 2020 , https://www.sciencealert.com/genetic-analysis-shows-wuhan-coronavirus-is-similar-to-sars .

[13] https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/872567/medicines_that_cannot_be_parallel_exported_from_the_uk_13_march_2020.csv/preview

[14] http://doc.irasia.com/listco/hk/tfkf/announcement/a224851-e_01312ann_20200203(20200203_1952).pdf

[15] All information in this section is from: https://www.sciencealert.com/genetic-analysis-shows-wuhan-coronavirus-is-similar-to-sars , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147684/ , https://virologyj.biomedcentral.com/articles/10.1186/s12985-019-1182-0#citeas , Thomas R. Broker, PhD, Stanford University School of Medicine, Telephone discussion March 12, 2020.

[16] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/006002s044lbl.pdf , https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varApplNo=006002 , https://www.cdc.gov/malaria/resources/pdf/fsp/drugs/Chloroquine.pdf

[17] See Safety citations.

[18] Steve Schow PhD, https://sparkmed.stanford.edu/about-spark/who-we-are/ . Email correspondence March 2020.

God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The EVIL And Their Followers.

US Has Little To Fear.

US Has Little To Fear.

Bayer has donated 3 million Chloroquine pills. Enough pills to treat over 200,000 patients. With only 20% of those infected, requiring any additional treatment, this should cover existing cases and near future cases adequately until further stocks can be obtained. Do NOT panic. If you are showing high fever and shortness of breath, you should contact your healthcare provider/primary physician/CDC Coronavirus hotline.

sick-with-2019-nCoV-fact-sheet

The US response is beyond adequate, and many would say, more than necessary. The response around the world and in the US, would make you think that someone just released an out of control biological weapon with no cure or effective treatment. You can see from the above articles that there is an effective treatment, and that a cure/vaccine is well under way to being developed. The American People should call their elderly often, making sure that they are okay and that they are loved and cared for. The social distancing and quarantine measures are meant to keep our elderly safe.

God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The EVIL And Their Followers.

Michael, A Prince Of Heaven.

Michael, A Prince Of Heaven. Prophecy is now coming true. We are in the EndTimes. When I was 7 years old, I was taken from my home, and brought to a craft that was resting by the river near my home. I have no memory of what the occupants or the craft look like. I was seated near a window, and the craft rose til I was looking at the globe of the Earth. I was told that I was a Prince, and to find my way back. I was imprinted with a path that my life would take. I remember walking back home on the street, but I do not remember entering my home or returning to bed. From that day forward I was obsessed with star travel and developing myself into a Prince. I told no one that I was a Prince, but I began learning everything that I could. I have always been considered a freak and nerd. I have always been different, but at least I was allowed a somewhat normal life.

Shortly after that first encounter I was given a vision one night in the room I shared with my brother and grandmother. I woke up and looked at the foot of my bed, and I saw a young man with glasses, long hair, jeans and jean jacket, and he was carrying many books in his arms, and he had a pained look on his face. He started walking towards me and I screamed. He disappeared and my family came rushing to me. I was told by my parents that it was just a nightmare. My mother lit the candle at the Virgin Mary stature and rocked me until I was calm enough to sleep again. I have always remembered that event, but I did not understand it until 10 years later. I looked into the mirror at 17 and realized that they had shown me myself in the future.

When I was 8-9 and playing in the park with toy binoculars I saw a gold bullet with 4 antennas traveling in the sky slowly moving east. Being young I assumed it was just a satellite. Years later I realized that satellites are much smaller and would burn up like an asteroid.

I was always reading about rockets, UFOs, Aliens, science fiction, NASA, science, math, telescopes, microscopes, and many other strange subjects for a young boy. I was unable to participate in sports due to breathing problems. My first time in a hospital was 6 months old. I later grew out of it at 18 and became a US Marine at 19.

When I was 14-15 I was walking our dog in the park, and saw a dash of light in the distant sky going up and down, and then side to side, and repeating. I know that it was a real craft due to fighter jets and bombers from the nearby airbase went after it. When they reached the area it was in, it shot straight up and was gone, and then the fighters and bombers returned to the airbase.

Similar to this though smaller and glowing at night.

When I was in junior high school I bought nuclear physics books from the main library book sale and was studying those. Public schools in my days did not double promote or advance gifted individuals. I had to see counselors in junior high and high schools because they were worried about how I was being picked on by other students and wanted to make sure that I would not snap. Many times teachers would apologize to me for not being able to teach me at my speed. When I went into the US Marines I was an air traffic control communications technician. I also cross trained in navigation equipment, and was cross training in radar equipment when I left. I was in the US Marines for 4 years, and strangely, we had no major operations, only training operations.

My first full time job was building 17 ton magnets for Los Alamos laboratories for proton containment. The company was also making the magnetic x-ray, known as the MRI today. I was laid off because the magnets were finished(11 of them), and the magnetic x-ray was having problems still. I then went to work at a cryogenics company where I ended working on the large units testing. I left that company when an opening came up to build 4-7 ton magnets at another company. I then went into the US Marines. After the US Marines I went into time equipment service repair and fire alarm training. We then had a recession and I worked with my father doing flooring, carpet and tile mostly. After that I went into fire alarms and sprinklers. Then I went into fire, security, and access control. Then I went into security and locksmithing. Now I am on my own and still have not gotten anywhere. It makes no sense.

When I was in high school I knew the speed of light could be surpassed and proved it using relativity. I also suspected that a generator could be powered by a motor and create more electricity than it uses. When I was 23 I came out with the photon coil. I tried to teach humanity the new technology but you failed to understand it, or were kept from understanding it. It was then that I began studying religion and found out that I was in the prophecies. I have been waiting for the EndTimes since then. The Sun and Moon shifting was the final sign.

I have been analyzing this world, its people, its history, its development, and its future. I have concluded that anyone in the United States has access to enough information to advance themselves and progress forward in technological development if they only wanted to. I have also concluded that there are two parallel paths that must be followed to enter Heaven. Religion and Science.

I was appointed to my position at age 7. I have lived on Earth and suffered at your ignorance and stupidity. I have had to advance myself mentally, while being kept poor and living in poverty. I have been trying to teach you for almost thirty years now. My faith has kept me going and I created these websites to bring you my enlightenment, in hopes of saving as many of you as possible. Satan-Devil-Lucifer says to God-Allah-Yahweh that you are unworthy to be called an intelligent creation, and that you are not capable or worthy of entering Heaven. I have lived among you, and some of you are very good people. Many of you are misguided though, because you believe in the lies and deceptions that are being fed to you constantly. Heaven is NOT entered in death or spirit. At Judgement Day, if your life is over, your recorded soul will be judged, and if you are worthy of Heaven, your Body and Life will be restored. If you are deemed unworthy, I believe, your recorded soul will be placed in a system called Hell, where you will be tormented and tortured, in the manner that you treated your fellow humans, and you shall remain there until God-Allah-Yahweh decides to have mercy, and shut down the system. I want you to advance and make yourselves worthy. Forgiveness is possible while you still live, but it must be sincere and lasting, and you must strive for righteousness, and become Righteous. God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The EVIL And Their Followers.

Please Donate so I can lead you to Heaven.

US President Only Adding Additional Sanctions.

US President Only Adding Additional Sanctions. US President Trump has just finished a press conference and no military strikes will be made against Iran due to no American or Iraqi deaths and minimal damage to US military bases.

https://www.breitbart.com/middle-east/2020/01/08/klein-iran-claims-its-not-seeking-escalation-after-attacking-u-s-embassy-and-bombing-american-troops/

https://www.breitbart.com/politics/2020/01/08/watch-live-president-donald-trump-addresses-the-nation-after-iran-missile-attacks/

https://www.breitbart.com/politics/2020/01/07/exclusive-matt-gaetz-trump-doctrine-best-when-u-s-strikes-terrorists-bring-troops-home/

https://www.breitbart.com/clips/2020/01/08/gaetz-obama-biden-policy-blame-iran-situation/

https://www.breitbart.com/clips/2020/01/07/cruz-missiles-fired-iran-u-s-base-paid-billions-obama/

https://www.breitbart.com/europe/2020/01/08/176-dead-include-63-canadians-three-brits-after-boeing-737-crashes-in-iran/

https://www.breitbart.com/national-security/2020/01/08/iran-refuses-to-hand-over-black-boxes-from-crashed-ukrainian-passenger-jet/

https://www.breitbart.com/europe/2020/01/08/germany-withdraws-troops-from-iraq-as-iran-tensions-continue/

https://www.breitbart.com/clips/2020/01/07/graham-trump-has-all-the-authority-he-needs-to-respond-to-missile-strike/

https://www.breitbart.com/national-security/2020/01/07/pentagon-confirms-iran-launching-dozens-of-missiles-at-u-s-targets-in-iraq/

https://www.breitbart.com/national-security/2020/01/07/nancy-pelosi-blames-trump-for-iran-attack-as-u-s-troops-under-fire/

https://www.breitbart.com/politics/2020/01/07/nancy-pelosi-dodged-mike-pence-phone-call-notifying-her-of-iranian-missile-attack-tell-him-ill-call-him-back/

https://www.breitbart.com/politics/2020/01/07/donald-trump-reacts-to-iran-missile-strikes-all-is-well/

https://www.breitbart.com/economy/2020/01/07/futures-recover-as-iran-war-panic-subsides/

https://www.breitbart.com/national-security/2020/01/07/left-blames-trump-for-iran-attack-on-u-s-troops/

https://www.breitbart.com/politics/2020/01/07/white-house-dunks-on-cnn-over-irresponsible-reporting-during-iran-attack/

https://www.breitbart.com/clips/2020/01/07/house-foreign-affairs-chair-engel-this-could-very-well-be-war-with-iran/

https://www.breitbart.com/clips/2020/01/07/gop-rep-rogers-i-think-trump-will-de-escalate-with-iran-no-need-for-more-force/

https://www.breitbart.com/the-media/2020/01/07/nolte-watch-state-dept-spokesperson-humiliate-cnn-anchor-with-3-iran-fact-checks/

https://www.breitbart.com/clips/2020/01/07/fncs-griffin-pompeos-baffling-claim-irans-support-taliban-network-exaggeration-best/

https://www.breitbart.com/clips/2020/01/07/biden-trump-does-not-get-benefit-of-the-doubt-on-iran/

https://www.breitbart.com/national-security/2020/01/07/trump-backs-away-from-threat-to-attack-iran-cultural-sites/

https://www.breitbart.com/politics/2020/01/07/new-york-times-defends-soleimani-says-iran-is-in-mourning/

https://www.breitbart.com/national-security/2020/01/07/mike-pompeo-soleimani-airstrike-saved-american-lives/

https://www.breitbart.com/middle-east/2020/01/07/the-nuclear-option-soleimani-is-dead-and-america-first-is-alive/

https://www.msn.com/en-us/news/politics/trump-doesnt-signal-further-military-strikes-after-irans-attack/ar-BBYJP2r

https://www.msn.com/en-us/news/world/us-suspects-iran-reprisal-deliberately-missed-american-troops/ar-BBYIzUq

https://www.msn.com/en-us/news/politics/this-was-an-act-of-war-lawmakers-react-to-irans-missile-strike-on-us-military-bases/ar-BBYIAI0

https://www.msn.com/en-us/news/world/boeing-737-plane-crash-in-iran-prompts-conflicting-statements/ar-BBYIQLr

https://www.msn.com/en-us/news/world/iran-fires-on-us-forces-at-2-bases-in-iraq-calling-it-fierce-revenge/ar-BBYHQGh

https://www.msn.com/en-us/news/world/irans-strikes-seem-intended-to-avoid-us-deaths-heres-why-that-might-be-the-case/ar-BBYJPme

https://www.msn.com/en-us/news/other/faa-issues-emergency-restriction-for-iraq-iran-persian-gulf-airspace-after-iran-missile-attacks/ar-BBYIIy2

https://www.msn.com/en-us/news/politics/iran-strikes-could-stall-democrats-plans-for-war-powers-resolution-vote/ar-BBYKhSC

https://www.msn.com/en-us/news/politics/trump-aides-to-brief-congress-on-iran-as-tehran-retaliates-over-killing-of-gen-qasem-soleimani/ar-BBYJLOR

https://www.msn.com/en-us/news/politics/poll-47-percent-approve-of-trump-strike-on-soleimani/ar-BBYJVL4

https://www.msn.com/en-us/news/politics/a-strategy-for-the-mideast-that-has-even-trumps-allies-scratching-their-heads/ar-BBYINwq

https://www.msn.com/en-us/news/politics/this-was-an-act-of-war-lawmakers-react-to-irans-missile-strike-on-us-military-bases/ar-BBYIAI0

https://www.msn.com/en-us/news/us/were-going-to-war-bro-fort-braggs-82nd-airborne-deploys-to-the-middle-east/ar-BBYHjjo

https://www.msn.com/en-us/news/us/the-us-military-arsenal-a-look-at-americas-most-significant-weaponry/ar-BBYJkdo

https://www.msn.com/en-us/news/politics/iranian-attack-scrambles-house-war-powers-vote/ar-BBYIIiG

https://www.msn.com/en-us/news/politics/pressed-for-details-on-suleimani-strike-trump-administration-gives-few/ar-BBYIDS4

https://www.msn.com/en-us/news/politics/top-lawmakers-call-for-prayer-unification-in-wake-of-iran-attack/ar-BBYIMKQ

https://www.msn.com/en-us/news/world/at-the-edge-of-a-war-us-and-iran-appear-to-step-back/ar-BBYKkoK

https://www.msn.com/en-us/news/politics/trump-doesnt-signal-further-military-strikes-after-irans-attack/ar-BBYJP2r

https://www.msn.com/en-us/news/world/us-knew-iranian-missiles-were-coming-ahead-of-strike-trump-announces-new-sanctions/ar-BBYJVM6

https://www.msn.com/en-us/news/world/irans-strikes-seem-intended-to-avoid-us-deaths-heres-why-that-might-be-the-case/ar-BBYJPme

These are all the articles relating to Iran, in the news today. It appears that Iran and the United States of America are standing down military escalation at this time. The United States of America could have destroyed many targets inside Iran including missile bases, refineries, nuclear facilities, and military bases, but did not. Why? Many people are wondering why Iran’s strike appears to be for show. Iran news claims heavy damage and 80 Americans dead to its people. US President Trump has claimed no deaths and only minimal damage.

The United States of America has failed to respond to an attack directed at our military bases in Iraq. Why? Was the Iranian attack staged to save face and provide propaganda for its people? The reports seem to confirm this. The world economy could have been affected by the conflict, but it seems that the United States of America has been talked into playing along with the staged event so Iran can make itself look strong. The American People are disappointed that we did not, at a minimum take out the missile sites and at least their nuclear sites. We can only hope that the Trump Administration has not made an error. The nuclear capabilities and pursuit of nuclear weapons pose the greatest threat to Israel and the USA. We shall see what happens in the future. The prophecies may have been fulfilled with this show, and may be the reason it was done.

God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The EVIL And Their Followers.

Death To Iran ???

Death To Iran ??? God-Allah-Yahweh is fighting EVIL and its followers. Iran also known as Persia has been teaching Hate and Violence against the Children of God-Allah-Yahweh who believe in him. God-Allah-Yahweh is the ‘God of Abraham’ and the Christians, Muslims, and Jews, all worship him. The chants of ‘Death to Israel’ and ‘Death to America’, are against the Teachings of God-Allah-Yahweh. Iran-Persia is violating the Covenants and Commandments of God-Allah-Yahweh, and is threatening the Nations that were created and blessed him, Israel and the United States of America.

Israel is NOT the enemy of God-Allah-Yahweh, but his Chosen People. The United States of America is NOT the enemy of God-Allah-Yahweh, but a nation created upon the Laws of God-Allah-Yahweh and Blessed by him.

The United States of America is the Most Powerful Nation on Earth, but it does NOT seek to conquer the Earth. God-Allah-Yahweh has made the USA his Army of the Righteous. Iran-Persia will be destroyed if God-Allah-Yahweh pushes them into war with the USA. Iran-Persia must change its ways and follow the Laws and Teachings of God-Allah-Yahweh, or face destruction.

The United States of America has the capability of destroying the entire world many times over. The USA has saved the world many times from those who would conquer and enslave it.

The USSR was the last threat and super power that the USA faced. The world was in threat of destruction and the cold war needs to be remembered.

The last attack on the USA homeland caused the country of Afghanistan to have its government conquered and replaced.

The USA is now battling terrorism worldwide to make sure it remains safe, and will continue to battle the forces of EVIL that threaten it.

The USA believes in God-Allah-Yahweh and Heaven-Hell. The EVIL and their followers shall NOT triumph over the USA, or Israel, for both are Blessed and Protected by God-Allah-Yahweh. Iran-Persia must change its ways and follow the Laws and Covenants of God-Allah-Yahweh.

God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The EVIL And Their Followers.

God-Allah-Yahweh Never Said Everyone Goes To Heaven.

God-Allah-Yahweh Never Said Everyone Goes To Heaven. He gave you his Laws and Commandments, and told you that everything you do is recorded. He told you that he would have a Judgement Day, and that even after death, he can bring you back and judge you. He gave you many Teachers and Prophets to instruct you in the ways of GOOD-EVIL and Righteous-Unrighteous Ways.

Remember that you must make yourself Worthy of Heaven. God-Allah-Yahweh told US about the Rewards and Punishments he would place upon US.

God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The And Their Followers.

God-Allah-Yahweh Is Watching The United States Of America.

God-Allah-Yahweh Is Watching The United States Of America. US President Donald Trump will not be crucified, but he is being treated the same way you treated Jesus of Nazareth. You are being watched and your actions and deeds will be used to Judge if you are Worthy to enter Heaven. The nation created with Freedom and Justice For All, is about to tested and it is unsure that it will pass. President Trump has rebuilt the US Military, the US Economy, and Faith in God-Allah-Yahweh. He has created the Space Force and is pursuing space exploration. He has appointed Constitutional Judges and Justices. He has reduced crime and reformed criminal justice, as well as supported all law enforcement.

God-Allah-Yahweh May You Keep Humanity From Making The Same Mistake As They Made In The Past. God-Allah-Yahweh Bless And Protect The Righteous, And Curse And Confuse The EVIL And Their Followers.